哺乳动物细胞自噬关键节点及相关药物的研究进展

Research progress of the key targets of autophagy and related drugs in mammalian cells

自噬是一种在压力条件下被激活的可降解和循环利用大分子和细胞器的代谢过程。自噬对维持细胞内环境的稳态有重要作用,并与许多疾病尤其是肿瘤的发生发展息息相关,这使得以调控自噬为靶标的新药开发及临床治疗研究越来越受到瞩目。但是,自噬过程的调控机制非常复杂,本文就目前受到关注的涉及自噬信号通路的mTOR、ULK、Beclin-1、Atg12连接系统、LC3脂质化连接系统、p62等关键节点及相关药物研究进展做一介绍。

Autophagy is a catabolic process for the degradation and recycling of macromolecules and organelles,which is activated during stress conditions. It plays an important role in maintain a homeostasis in the cell,and is closely related to many diseases, especially the development of tumor,which makes researchers pay more attention on control autophagy as a target of new drug development and clinical application. However,the mechanism of autophagy process is very complicated. This article reviews the research progress of crucial targets mTOR,ULK,Beclin 1,Atg12 connection system,LC3 lipid connection system and p62/SQSM1,which are involved in autophagy signaling pathways and its related drugs.