小肠腺癌发病机制研究进展

Research progress in mechanisms of small bowel adenocarcinoma

小肠腺癌(small bowel adenocarcinoma,SBA)是临床相对罕见的恶性肿瘤,总体生存率低,预后差。近年研究表明,环境因素及遗传因素对其发病起一定作用。此外,多种基因突变、DNA甲基化、DNA错配修复和微卫星不稳定及相关信号通路异常激活参与了SBA的发生、发展。但其发病机制尚未完全阐明,需进一步深入研究,以期为SBA临床诊治及预后判断提供理论依据和新思路。

Small bowel adenocarcinoma（ SBA）is a rare malignant tumor with poor prognosis and low overall survival. Researches of recent years have shown that the environmental factors and genetic factors play a role in the development of SBA. In addition,a variety of genetic mutations,DNA methylation,DNA mismatch repair,microsatellite instability and related signal pathways were activated abnormally involved in the occurrence and development of SBA. However,the pathogenesis of SBA is not completely clear and further research should be performed to provide theoretical basis and new ideas for the clinical diagnosis,treatment and prognosis of SBA.