面部脂溢性皮炎外用药物治疗效果的定量观察

Quantitative analysis of the therapeutic effect of topical medication for seborrheic dermatitis

将2016年2—7月在宣武医院皮肤科门诊就诊的51例面部脂溢性皮炎患者，按就诊顺序号单数者为试验组（28例）、双数者为对照组（23例）分组，分别给予透明质酸凝胶和他克莫司软膏治疗28 d。每次随访行问卷调查评价药物疗效，同时使用VISIA皮肤图像分析仪对患者的皮肤指标进行定量分析。治疗后，试验组和对照组有效率分别为89%（25/28）和91%（21/23），差异无统计学意义（P〉0.05）；VISIA结果显示与治疗前相比，两组患者斑点、红色区特征计数减少，差异有统计学意义（均P〈0.05）,两组比较差异均无统计学意义（均P〉0.05）。试验组无不良反应发生，对照组3例在用药第2天出现皮肤瘙痒伴有烧灼感，继续用药后症状逐渐消失。提示透明质酸凝胶治疗面部脂溢性皮炎的疗效与他克莫司软膏相当，且安全无刺激性；VISIA皮肤图像分析仪可为脂溢性皮炎提供客观、有效的定量评价方法。

Fifty one female outpatients with facial seborrheic dermatitis attending in Xuanwu Hospital during February 2016 to July 2016 were randomly assigned in two groups： 28 patients were treated with hyaluronic acid gel （ study group） and 23 patients were treated with tacrolimus ointment （ control group） for 28 days. The improvement of symptoms after treatment was observed by a questionnaire, and VISIA was used to quantify the skin index of the patients. There was no difference in the therapeutic effect between the study group and control group after 28 days （ P 〉 0.05 ）. The facial spots and red areas were decreased in both groups, compared to those before treatment （P 〈 0.05）. The results indicate that hyaluronic acid gel is safe, non-irritating and effective in treatment of seborrheic dermatitis, and VISIA provides an objective and effective method for assessing the skin lesions seborrheic dermatitis.