常见骨原发肿瘤研究新进展

New progress of common primary bone tumors

原发性骨肿瘤发病率相对较低,其中常见的恶性骨肿瘤包含骨肉瘤、尤文肉瘤及软骨肉瘤。骨巨细胞瘤（giant cell tumor,GCT）属中间性肿瘤。恶性骨肿瘤易复发和转移,恶性程度较高,并可影响患者运动功能。骨肿瘤的发病机制尚不清楚,临床治疗上仍有很大提高空间,许多方面需要更多深入研究。笔者旨在对常见原发性骨肿瘤：骨肉瘤、尤文肉瘤、软骨肉瘤以及GCT的近年的亮点研究进行系统综述。

Malignant tumors of the musculoskeletal system are aggressive, with a high chance of systemic spread. In recent years, with the popularization of the neoadjuvant chemotherapy and extensive resection, and the improvement of reconstruction techniques, the treatment of malignant bone tumors has entered a relatively mature stage. But it has entered a bottleneck. In the past 30 years, the survival rate of osteosarcoma had improved little. Many of the basic science researches regarding sarcoma focus on molecular pathways and the identification of targets of systemic therapy. Researchers are focusing on identifying the potential benefits of these techniques with regard to local control and lessening of wound complications. The purpose of this article is to present some of the advances in the research and treatment of malignant and intermediate musculoskeletal tumors.