中药活性成分抗肺纤维化及机制研究概况

Advances of Active Components in Traditional Chinese Medicine for Treating Pulmonary Fibrosis and the Preventive Mechanisms

目的:中药活性成分抗肺纤维化及其机制研究进展。方法:肺纤维化(pulmonary fibrosis,PF)是一种以弥漫性、进行性肺间质纤维增生和肺泡结构紊乱并最终导致肺功能障碍为特点的呼吸系统疾病。结果:其病理特征是肺泡上皮损伤、成纤维细胞灶的形成以及细胞外基质的过度沉积,最终导致了肺组织结构的异常重塑。PF的病因复杂,预后极差,临床尚无公认有效的治疗手段。结论:近年来,随着国内外学者对PF发病机制研究的逐渐深入和治疗方法的不断探索,有关中药活性成分治疗PF的实验研究及其抗PF机制取得了较大进展。

Objective： Active components in traditional Chinese medicine for treating pulmonary fibrosis and its preventive mechanisms. Methods： Pulmonary fibrosis（PF） is a respiratory disease characterized by diffuse and progressive fibroplasia of pulmonary interstitial, as well as damaged alveolar structure which eventually lead to lung dysfunction.Results： Its pathological characteristics are alveolar epithelial injury, the formation of fibroblast foci and excessive deposition of extracellular matrix（ECM）, and finally result in abnormal remodeling of the lung tissue structure. Etiology of pulmonary fibrosis is complex and it has poor prognosis without generally accepted effective treatments in clinical.Conclusions： In recent years, along with the gradually further researches and continuously treating exploration on the pathogenesis of pulmonary fibrosis by domestic and foreign scholars, experimental researches of active components in traditional Chinese medicine for the treatment of pulmonary fibrosis and its preventive mechanisms has made great progress.