预防性抗菌治疗对HIV感染孕产妇妊娠结局的影响

Affectof Preventive Antibiotic Therapy on Pregnancy Outcome of Pregnant Women with HIV Infection

目的预防性抗菌治疗对HIV感染孕产妇妊娠结局的影响。方法对我院2011年11月至2016年11月收治的80例HIV感染孕产妇患者的临床资料进行回顾性分析。将这些患者分为对照组和观察组各40例。剖宫产术前预防性抗菌治疗一次为对照组,预防性抗菌治疗延至48h为观察组,比较两组对HIV感染孕产妇妊娠结局的影响。结果当CD_4^+T淋巴细胞≥350个/μL时,观察组在产后出血、产后感染、伤口愈合情况、住院时间等指标较对照组差异无统计学意义(P>0.05),而当CD_4^+T淋巴细胞<350个/μL时,两组差异有统计学意义(P<0.05)。结论 HIV感染孕产妇剖宫产预防性抗菌治疗维持时间与CD_4^+T淋巴细胞计数有关,当CD_4^+T淋巴细胞<350个/μL(尤其<200个/μL)时延长预防性抗菌治疗至48h是必要的。

Objective Affect of preventive antibiotic therapy on pregnancy outcome of pregnant women with HIV injection. Methods In our hospital between November 2011 and November 2016 ,the clinical data of 80 pregnant women with HIV infection were analyzed retrospectively. These patients were evenly divided into control group and observation group. The use of one preventive antibiotic treatment In the cesarean section as the control group, preventive antibiotic therapy was extended to 48 hours as the observation group, compared the effects of the two groups on the pregnancy outcomes of HIV-infected pregnant women. Results When the CD4 T lymphocytes≥350/uL,there were no significant differences between the observation group and the control group in postpartum hemorrhage, postpartum infection ,wound healing and hospitalization time （P 〉 0.05 ） ;While when CD 4^＋ T lymphocytes 〈 350/uL, there was significant difference between the two groups （P0.05）. Conclusion The duration of prophylactic antibiotic therapy for cesarean section in HIV-infected pregnant women was related to CD4^＋ T-lymphocyte count. When CD4^＋ T-lymphocytes 〈 350/UL（ especially 〈 200/uL）, prolonged prophylactic antibiotic therapy to 48 hours is necessary.