98例胃肠胰神经内分泌肿瘤的临床病理特征及生存分析

Clinicopathological features and survival analysis of 98 patients with gastroenteropancreatic neuroendocrine neoplasms

目的:探讨98例胃肠胰神经内分泌肿瘤的临床、病理特点及预后因素,以提高对该疾病的认识及诊治水平。方法:选取2008年1月至2016年6月新疆医科大学附属肿瘤医院收治98例资料完整的胃肠胰神经内分泌肿瘤患者的临床资料,对其临床表现、病理特征、生存等进行回顾性分析。结果:本组患者共98例(男67例,女31例),平均年龄(54.5±12.8)岁,发病部位最常见于胃(33/98,33.7%),其次直肠(31/98、31.6%)。肿瘤大小0.2至9.2厘米(平均:1.2厘米)。平均随访时间为18个月(范围1~101个月)。患者1年、3年和5年总生存率分别为80.6%、64.1%、56.2%。单因素分析显示肿瘤部位、大小、分级、淋巴结转移、远处转移及手术方式是预后不良的预测因子,多因素分析未发现任何独立的危险因素。结论:胃肠胰神经内分泌肿瘤是一种少见的疾病,临床表现不典型,最常见的发生部位是胃,多为高度恶性肿瘤;其次多见于直肠,多为低度恶性肿瘤。胃肠胰神经内分泌肿瘤以手术治疗为主。

Objective：To investigate the clinicopathological features and prognostic factors of 98 patients with gastrointestinal pancreatic neuroendocrine tumors,so as to improve their understanding and diagnosis and treatment level.Methods：The data of 98 patients with gastrointestinal pancreatic neuroendocrine tumors were collected from January 2008 to June 2016 in Xinjiang Tumor Hospital.Their clinical manifestations,pathological features and survival were retrospectively analyzed.Results：There were 98 cases （67 males and 31 females） with a mean age of （54.5±12.8） years.The incidence of the disease was most common in stomach （33/98,33.7%）,followed by rectum （31/98,31.6%）.The tumor size ranged from 0.2 cm to 9.2 cm （mean size：1.2 cm）.The mean follow-up time was 18 months （range 1～101 months）.The 1,3 and 5-year overall survival rates were 80.6%、64.1%、56.2%,respectively.Univariate analysis showed that tumor location,size,grade,lymph node metastasis,distant metastasis and surgical methods were poor prognostic factors.Multivariate analysis did not reveal any independent risk factors.Conclusion：Gastrointestinal pancreatic neuroendocrine tumor is a rare disease,the clinical manifestations are not typical,the most common place is the stomach,mostly high-grade malignancy,followed by the more common in the rectum,mostly low-grade malignancies.Gastrointestinal pancreatic neuroendocrine tumors to surgical treatment based.