肿瘤细胞的命运

Cell fates in human cancers

肿瘤细胞有不同于正常细胞的命运,这些命运包括细胞复制、衰老、死亡、休眠、变异、重构和挤出。肿瘤遗传和表观遗传决定了细胞的命运,理解肿瘤细胞不同的命运可能会发现新的肿瘤治疗方法。抑制肿瘤细胞复制、变异、重构和挤出,或诱导肿瘤细胞衰老、死亡和休眠,从而改变肿瘤细胞的命运可实现治疗肿瘤的目的。

Cancer cells fates differ from human normal cells.The fates of cancer cells include cell division,senescence,death,dormancy,derivation,reprogramming and extrusion.Cancer cell fates are controlled by the genome and the epigenome.Understanding various fates can discover novel methods for cancer management.Inhibiting cell division,derivation,reprogramming,extrusion,or inducing cell senescence,death and dormancy may change cancer cells fates and achieve cure for cancer patients.