摘要
B细胞在体液免疫中发挥重要作用,并通过分泌各种抗体促进细胞免疫。调节性B细胞是近年来发现的存在于B细胞中的一种新的细胞亚群,其主要通过分泌IL-10、、IL-35等来抑制过度炎症反应,研究表明其在自身免疫疾病、移植免疫、肿瘤免疫、感染免疫中发挥着重要的作用。本文就调节性B细胞的来源、功能、作用机制及相关研究进展作一综述。
B cells play an important role in humoral immunity and promote cellular immunity by secreting various antibodies.In recent years,a new subset of cells found in B cells have been named regulatory B cells. Breg cells suppress excessive inflammatory responses mainly by secreting interleukin （IL）-10,IL-35 and so on. Breg cells play an important role in autoimmune diseases,transplantation immunity,tumor immunity and infection immunity.Therefore,this review summarizes the sources,functions,mechanisms and related research progress of regulatory B cells .
出处
《现代肿瘤医学》
CAS
2018年第7期1132-1135,共4页
Journal of Modern Oncology
基金
国家自然科学基金资助项目(编号:81600115)
关键词
Breg细胞
免疫疾病
研究进展
breg cells
immunologically mediated disease
research progress
