TACE联合体部伽玛刀治疗巨块型肝癌的临床观察

The clinical of observation of TACE combinied with body gamma knife radiotherapy for the treatment of huge hepatocellular carcinoma

目的:探讨肝动脉化疗栓塞术(trashepatic arterial chem otherapy and embolization,TACE)联合体部伽玛刀治疗巨块型原发性肝癌的疗效及毒副反应。方法:对38例非手术治疗的巨块型肝癌患者行TACE联合体部伽玛刀治疗,伽玛刀治疗结束后4周行肝脏CT或MRI检查评价疗效,以后定期随访复查。结果:近期疗效:完全缓解(CR)0例,部分缓解(PR)23例,稳定(SD)12例,进展(PD)3例,近期总有效率(RR)92.1%。1、3、5年生存率分别为81.6%、10.5%、5.3%。主要毒副反应为消化道反应、骨髓抑制及放射性肝炎,患者均能耐受。结论:TACE联合体部伽玛刀治疗巨块型肝癌的效果好,毒副反应较轻。

Objective：To evaluate the clinical efficacy and side reactions of TACE combined with body gamma knife radiotherapy for patients with huge hepatocellular carcinoma. Methods：38 cases of non - surgical treatment of huge hepatecellular carcinoma patients were treatment by TACE combined with body gamma knife radiotherapy. 4 weeks after gamma knife treatment, hepatic CT or MRI examinations were performed to evaluate the efficacy. All pa- tients were followed up and reexamined regularly. Results： Short - term effictive ： complete remission in 0 cases, partial remission in 23 cases,stable disease in 12 cases,progress disease in 3 cases,and the short - term effective rate was 92.1%. The 1,3 and 5 years survival rate was gl. 6% , 10.5% and 5.3% respectively. The main adverse events were digestive tract reaction, myelosuppression and radioactive hepatitis. All of the patients were tolerable. Conclusion ： TA- CE combined with body gamma knife radiotherapy for the treatment of patients with huge hepatocellular carcinoma has good effect with mild side reactions.