血管紧张素受体AT1R与肿瘤血管形成关系的研究进展

Progress in study of the relationship between AT1R and tumor angiogenesis

肾素血管紧张素系统(renin-angiotensin-system,RAS)主要的生理作用是维持心血管功能稳态、电解质和体液平衡、调节血压,但是在一些恶性肿瘤中发现其局部活化。血管紧张素II是肾素血管紧张素系统中重要的成分,在肿瘤的生长、转移、血管的生成过程中发挥关键作用。在不同的肿瘤中可通过与血管紧张素Ⅱ型1受体(angiotensin Ⅱ type 1 receptor,AT1R)结合,激活相关信号通路引起血管生成相关因子的升高,促进血管生成,加速肿瘤进展。而AT1R的拮抗剂又能明显抑制或逆转这种生物效应,这些结果提示着AT1R将可能会成为肿瘤治疗新的分子靶点。

The renin - angiotensin system （renin - angiotensin - system,RAS） the main physiological function is the maintenance of cardiovascular homeostasis, electrolyte and fluid balance, regulating blood pressure, but in some malignant tumors found in the local activation. Angiotensin II plays an important role in the process of tumor growth and metastasis. By combining with AT1 R （Angiotensin II type 1 Receptor, AT1 receptor） in different tumors, the activation of related signal pathways can lead to the increase of angiogenesis related factors, promote angiogenesis, and accelerate tumor progression. However, AT1 R antagonists can significantly inhibit or reverse this biological effect, which suggests that AT1 R may be a new molecular target for cancer therapy.