维生素D与佝偻病/骨软化症

Vitamin D in rickets and osteomalacia

佝偻病与骨软化症是骨骼矿化障碍疾病。佝偻病/骨软化症的发病常与维生素D缺乏、代谢和作用异常相关。营养性维生素D缺乏是儿童佝偻病最主要的病因,维生素D代谢异常及受体异常也可导致其他类型佝偻病和骨软化症。治疗需根据不同病因,选择维生素D或其类似物。治疗中应注意监测血钙和尿钙水平,条件允许可酌情监测血清25羟维生素D和甲状旁腺素水平等指导治疗。

Rickets and osteomalacia are disorders of bone insufficient mineralization. Vitamin D plays important roles in pathogenesis of rickets and osteomalacia. Nutritional vitamin D deficiency is the major reason for rickets in childhood. Abnormalities of vitamin D metabolism or the vitamin D receptor cause some forms of rickets and osteomalacia. Vitamin D or its analogs therapy should be given depending on variable etiology. Serum and urinary calcium levels should be monitored in long-term regular follow-up. Serum 25 hydroxyvitamin D（ 25 OHD） or parathyroid hormone levels would be beneficial for directing treatment.