STAT3在食管胃交界部腺癌中的表达及意义

Expression and Significance of STAT3 in Adenocarcinoma of Esophagogastric Junction

目的检测信号转导与转录激活因子3(STAT3)在食管胃交界部腺癌中的表达,探讨其在癌症中的作用。方法采用免疫组织化学的方法,检测2015年6月至2016年12月被河南省肿瘤医院确诊为进展期食管胃交界部腺癌的67例癌症患者,及35例癌旁正常对照组织中STAT3及p-STAT3的表达,用t检验的方法分析两组间STAT3及p-STAT3的表达差异。结果 45例(67.2%)食管胃交界部腺癌高表达STAT3,22例(32.8%)低表达STAT3;34(50.7%)例高表达p-STAT3,33例(49.3%)低表达p-STAT3。且癌组织分化程度越高,STAT3及p-STAT的表达水平则越高。结论 STAT3可能与食管胃交界处腺癌的发生、发展有关,或可成为新的治疗靶点之一。

Objective To detect the expression of signal transducer and activator of transcription 3 （ STAT3 ） in adenocarcinoma of esophagogastric junction （AEJ） and explore its role in AEJ. Methods Immunohistochemical method was used to detect the expression of STAT3 and p-STAT3 in 67 cases of AEJ which were collected from June 2015 to December 2016 and diagnosed by Henan province tumor hospital. At the same time, 35 cases of normal control tissues were also measured. The difference of expression levels of STAT3 and p-STAT3 between the two groups was analyzed by t test. Results 45 cases （67.2%）AEJ had high expression of STAT3 and 22 cases （ 32. 8% ） with low expression. 34 （ 50. 7% ） cases AEJ had high expression of p-STAT3 and 33 （49.3%）had low expression. And the higher differentiation degree of cancer tissue, the higher the expression level of STAT3 and p- STAT3 were observed. Conclusion： STAT3 may be related to the occurrence and development of AEJ, and may be one of the new therapeutic targets.