盆腔器官脱垂与COL3A1基因多态性的Meta分析

The association between COL3A1 and pelvic organ prolapse:Systemic and Meta-Analysis

背景一些学者研究表明,胶原蛋白类型3α1(COL3A1)rs180025与盆腔器官脱垂的发生有一定关联性,而另外一些学者则持相反的意见。目的评估COL3A1基因多态性是否为盆腔器官脱垂发生的危险因素。方法从多个数据库包括Medline、Embase、万方、中国知网等检索相关文章,语言和国家不限,但所选文章均为病例对照研究。提取数据并采取RevMan5.2软件进行Meta分析。结果共纳入1274名参与者(701例病例和573例对照)。等位基因A vs G:OR=0.98,95%CI 0.67,1.43,P=0.92;纯合子模型AA vs GG,OR=1.51,95%CI 0.47,4.82,P=0.48;杂合子模型GA vs GG:OR=0.89,95%CI 0.69,0.14,P=0.37;显性模型GA+AA vs GG:OR=0.92,95%CI 0.63,1.33,P=0.65;隐性模型AA vs GA+AA:OR=1.64,95%CI 0.54,4.95,P=0.38。结论 COL3A1基因的多态性与盆腔器官脱垂的发生无明显相关性,但盆腔器官脱垂的发生可能和种族有关。

Objective Some studies have suggested that collagen type 3 alpha 1 （COL3A1） rs180025 is associated with pelvic organ prolapsed （POP）. And some studies hold the opposite idea. The purpose of this study was to evaluate whether collagen type 3 alpha 1 is a risk factor for pelvic organ prolapse. Methods Relevant literature sources were searched using databases including Medline, Embase, China National Knowledge Infrastructure （CNKI）, Wanfang until now. Search terms included ‘Pelvic Organ Prolapses’,‘Urogenital Prolapse’,‘Vaginal Vault Prolapses’ combined with ‘COL3A1’. There is no limit to the language and country in search of articles. But the selected articles are casecontrol studies. RevMan 5.0 were used for this metaanalysis. Results Five studies with a total of 1274 participants （701 cases and 573 controls） were included in the analysis. The results are as follows： Allele A vs G： OR=0.98, 95%CI 0671.43, P=0.92; Homozygous model AA vs GG OR=1.51, 95%CI 0.47-4.82, P=0.48; Heterozygous model GA vs GG：OR=0.89, 95%CI 0.69-.14, P=0.37; Dominant model GA＋AA vs GG： OR=0.92, 95%CI 0.63-1.33, P=0.65; Recessive model AA vs GA＋AA： OR=1.64, 95%CI 0.54-4.95, P=0.38.Conclusion According to consequence the mateanalysis, we could knew that there was no significant correlation between COL3A1 and the risk of POP. t The POP is related to the race.