双环醇治疗HBV再激活后肝功能异常临床效果分析

Analysis of clinical effect of bicyclol after treatment for HBV reactivation of abnormal liver function

目的分析双环醇治疗乙型肝炎病毒(HBV)再激活后肝功能异常的临床效果。方法选取中国人民解放军153中心医院收治的HBV再激活后肝功能异常患者88例,采取数字随机法,随机分成观察组(n=44)和对照组(n=44),两组均停止使用抗结核药物,对照组给予常规治疗,观察组在常规治疗基础上,加用双环醇治疗,比较两组临床效果及安全性。结果两组患者治疗后2、4周ALT水平均低于治疗前,差异均有统计学意义(P<0.05)。两组患者治疗后4周ALT水平均低于治疗后2周,差异均有统计学意义(P<0.05)。观察组治疗后2、4周ALT水平均低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后ALB、AST、TBIL水平均高于治疗前,差异均有统计学意义(P<0.05)。观察组患者治疗后ALB水平高于对照组,AST、TBIL水平低于对照组,差异均有统计学意义(P<0.05)。观察组患者治疗2、4周后ALT恢复至正常率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率均为0.00%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论双环醇治疗HBV再激活后肝功能异常的临床效果显著,并且较为安全,是可行性较高的治疗方法之一。

Objective To analyze clinical effect of bicyclol treatment of hepatitis b virus （ HBV ） reactivation of abnormal liver function. Methods Our hospital after HBV reactivation in patients with abnormal liver function of 88 cases, adopt digital random method, randomly divided into observation group （ n = 44 ） and control group （ n = 44 ）, two groups have stopped using anti - TB drugs, the control group given conventional treatment, observation group on the basis of conven- tional treatment, and treatment with bieyclol, comparing two groups clinical efficacy, and safety. Results Two groups of 2, 4 weeks after treatment in patients with ALT levels are lower than before treatment, differences were statistically sig- nificant （ P 〈 0. 05 ）. ALT level 4 weeks after treatment in both groups were less than 2 weeks after treatment, the differ- ences were statistically significant （ P 〈 0. 05 ）. Observation group 2, 4 weeks after treatment the ALT levels are lower than that of the control group, the differences were statistically significant （ P 〈 0. 05 ）. Propagated after treatment in both groups, AST, TBIL level are higher than that of before treatment, the differences were statistically significant （ P 〈 0. 05）. Observation group of patients after treatment propagated level higher than the control group, AST, TBIL level lower than that of the control group, the difference had statistical significance （ P 〈 0.05 ）. Observation group of patients after treatment of 2, 4 weeks ALT back to normal level is higher than the control group, the difference was statistically significant （ P 〈 0. 05 ）. Incidence of adverse reactions of the two groups were 0. 00% , two groups compare the incidence of adverse reactions, there was no statistically significant difference （P 〉 0. 05）. Conclusion Bieyclol treatment HBV reactivation of abnormal liver function clinical effect after is remarkable, and safer, which is one of the treatment of high feasibility.