抑亢汤治疗青春期多囊卵巢综合征的理论与临床探讨

Theoretical and Clinical Study on Treatment of Adolescent Polycystic Ovary Syndrome by Yi Kang Decoction

[目的]探讨抑亢汤治疗青春期多囊卵巢综合征(polycystic ovarian syndrome,PCOS)的理论依据和临床疗效。[方法]根据青春期PCOS的诊断标准及临床特点,从"肝为五脏之贼""室女经闭多血结""痰挟瘀血成巢囊"三方面论述此病与肝郁、痰瘀的关系,以此为依据解析抑亢汤的组方意义和临床应用价值,并举案例佐证。[结果]青春期PCOS与肝郁化火、痰瘀互结病机关系密切;临床应用抑亢汤清肝泻火、活血化痰治疗效果明显;通过案例证明抑亢汤能够调整患者月经周期,减轻痤疮、肥胖体征,降低血清促黄体生成素(luteotropic hormone,LH)、LH/卵泡刺激素(follicle stimulating hormone,FSH)比值及总睾酮(testosterone,T)水平。[结论]从肝经郁火、痰瘀互结病机入手,应用抑亢汤治疗青春期PCOS,临床实用,疗效显著,为早期干预此病提供了有效治疗手段。

[Objective]To study the theoretical basis and clinical efficacy of YiKang decoction in the treatment of pubertal polycystic ovary syndrome. [Methods] According to the diagnostic criteria and clinical characteristics of pubertal polycystic ovary syndrome, the relationship between this disease and liver depression, phlegm and blood stasis, is discussed in three aspeets,＂liver the thief of the five internal organs＂,＂as a result of blood accumulation, adolescent female encounters amenorrhoea＂,＂be the nest capsule due to phlegm and blood stasis＂. And take this as the basis, analyse component value and clinical application value of YiKang decoction and give example to cite. [Results] Pubertal polyeystic ovary syndrome was closely related to the pathogenesis of fire derived from stagnation of liver-Qi and syndrome of intermingled phlegm and blood stasis. Clinical application of YiKang decoction has obvious curative effect. In a case, it was proved that the YiKang decoction could adjust the menstrual cycle, reduce acne and obesity, reduce serum luteinizing hormone, luteinizing hormone/follicle stimulating hormone ratio and total testosterone value. [Conclusion] According to the pathogenesis of fire derived from stagnation of liver-Qi and syndrome of intermingled phlegm and blood stasis, the application of YiKang decoction for treatment of pubertal polycystic ovary syndrome, which has clinical utility and obvious curative effect, provides effective treatment for early intervention of the disease.