通心络胶囊联合硫酸氯吡格雷片治疗不稳定型心绞痛临床观察

Clinical Observation of Tongxinluo Capsules Combined with Clopidogrel Hydrogensulfate Tablets for Unstable Angina Pectoris

目的:观察在常规治疗基础上加用通心络胶囊联合硫酸氯吡格雷片治疗不稳定型心绞痛的临床疗效。方法:选取90例不稳定型心绞痛气虚血瘀证患者,随机分为2组各45例,2组均予常规治疗,对照组加服硫酸氯吡格雷片治疗,观察组以通心络胶囊联合硫酸氯吡格雷片治疗,治疗3周,比较2组治疗后的临床疗效,并检测2组患者治疗前后的血脂指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]及动脉粥样硬化黏附因子(血管细胞黏附因子-1、细胞间黏附因子-1)的表达水平。结果:治疗3周后,观察组总有效率高于对照组,差异均有统计学意义(P<0.05)。2组TC、TG、LDL-C、血清血管细胞黏附因子-1、细胞间黏附因子-1水平均低于治疗前,差异均有统计学意义(P<0.05),观察组各项指标值均低于对照组,差异均有统计学意义(P<0.05)。结论:在常规治疗基础上加用通心络胶囊联合硫酸氯吡格雷片治疗气虚血瘀型不稳定型心绞痛,可明显降低患者的血脂指标及动脉粥样硬化黏附因子的水平,有效抗血栓形成、抑制血小板聚集,进而改善机体的微循环,恢复心肌功能,有助于心肌的供氧,一定程度改善了血管内皮功能,疗效显著。

Objective： To observe the clinical effect of Tongxinluo capsules combined with clopidogrel hydrogensulfate tablets on the basis of routine therapy for unstable angina pectoris. Methods：Divided 90 cases of patients with unstable angina pectoris of qi deficiency and blood stasis syndrome into the observation group and the control group randomly, 45 cases in each group. Both groups were given routine therapy and clopidogrel hydrogensulfate tablets for treatment,while the observation group was additionally received Tongxinluo capsules. Both groups received treatment for 3 weeks. Compared clinical effect of both groups after treatment, and detected indexes of serum lipids which include total cholesterol（TC）,triglyceride（TG） and low density lipoprotein cholesterol（LDL-C） as well as expression levels of atherosclerosis adhesion molecules which include vascular cell adhesion molecule-1（VCAM-1） and intercellular adhesion molecule-1（ICAM-1） of patients in both groups before and after treatment. Results： After 3 weeks of treatment, the total effective rate of the observation group was higher than that of the control group, the difference being significant（P〈0.05）. Levels of TC,TG,LDL-C,VCAM-1 and ICAM-1 of both groups were lower than those before treatment（P〈0.05）; all index values in the observation group were lower than those in the control group,differences being significant（P〈0.05）. Conclusion：Tongxinluo capsules combined with clopidogrel hydrogensulfate tablets on the basis of routine therapy can obviously decrease serum lipids indexes and levels of atherosclerosis adhesion molecules,effectively resist thrombosis,inhibit platelet aggregation so as to improve body microcirculation and recover myocardial function in treating unstable angina pectoris of qi deficiency and blood stasis syndrome type, which has significant effect on myocardial oxygen delivery and improvement of vascular endothelial function.