苏黄止咳胶囊联合阿奇霉素治疗咳嗽变异性哮喘临床观察

Clinical Observation of Suhuang Zhike Capsules Combined with Azithromycin for Cough Variant Asthma

目的:观察苏黄止咳胶囊联合阿奇霉素治疗咳嗽变异性哮喘患者的临床疗效。方法:将92例咳嗽变异性哮喘风邪犯肺证患者按照随机数字表法分为观察组与对照组各46例。2组均予丙卡特罗及酮替芬作为基础治疗,对照组加用阿奇霉素分散片治疗,观察组以苏黄止咳胶囊联合阿奇霉素分散片治疗。2组疗程均为4周。观察2组患者治疗前后咳嗽评分、炎症介质白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)与血清免疫球蛋白E(IgE)、嗜酸性粒细胞(EOS)水平的变化,评定2组的临床疗效。结果:治疗后,观察组总有效率(93.48%)高于对照组(71.74%),差异有统计学意义(P<0.01)。2组咳嗽性质、咳嗽程度及咳嗽次数评分均较治疗前降低(P<0.05);观察组3项评分均低于对照组,差异均有统计学意义(P<0.05)。2组IL-6、TNF-α、IgE和EOS水平均较治疗前降低(P<0.05),观察组4项指标水平均低于对照组(P<0.05)。结论:在常规用药基础上加用苏黄止咳胶囊联合阿奇霉素治疗咳嗽变异性哮喘风邪犯肺证患者可有效改善临床症状,减轻炎性反应,提高免疫功能。

Objective： To observe the clinical effect of Suhuang Zhike capsules combined with azithromycin for cough variant asthma（CVA）. Methods：Divided 92 CVA patients with wind pathogen invading lung syndrome into the observation group and the control group randomly according to random number table method, 46 cases in each group. Both groups received procaterol, ketotifen and azithromycin for treatment, while the observation group additionally received Suhuang Zhike capsules. The course of treatment for both groups lasted for 4 weeks. Observed changes of cough scores and levels of inflammatory mediators interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α）,serum immunoglobulin E（IgE） and eosinophil（EOS） of patients in both groups before and after treatment. Evaluated clinical effect of patients in both groups. Results：After treatment, the total effective rate was 93.48% in the observation group, higher than 71.74% in the control group, the difference being significant（P〈0.01）. Scores of cough character, cough degree and cough times in both groups were decreased when compared with those before treatment（P〈0.05）;above three scores in the observation group were lower than those in the control group,differences being significant（P〈0.05）. Levels of IL-6,TNF-α,IgE and EOS in both groups were decreased when compared with those before treatment（P〈0.05）;levels of above four indexes in the observation group were lower than those in the control group（P〈0.05）. Conclusion：Suhuang Zhike capsules combined with azithromycin on the basis of routine therapy can effectively improve clinical symptoms of CVA patients with wind pathogen invading lung syndrome,relieve inflammatory reaction and enhance immune function of patients.