沙参麦冬汤加减联合西药治疗小儿顽固性咳嗽肺阴亏虚证临床观察

Clinical Observation of Modified Shashen Maidong Tang Combined with Western Medicine for Intractable Cough in Children with Deficiency of Lung Yin Syndrome

目的:观察沙参麦冬汤加减联合西药治疗小儿顽固性咳嗽肺阴亏虚证的临床疗效。方法:选取本院80例顽固性咳嗽肺阴亏虚证患儿,随机分为对照组和观察组各40例。对照组予抗炎、祛痰、止咳平喘等西药治疗,观察组在此基础上予沙参麦冬汤加减。治疗后比较2组临床疗效,记录2组治疗前后药物起效时间和咳嗽消失时间,统计复发率。结果:观察组的治愈率和总有效率分别为70.0%和95.0%,对照组治愈率和总有效率分别为22.5%和75.0%,2组治愈率及总有效率分别比较,差异均有统计学意义(P<0.01,P<0.05)。观察组的药物起效时间和咳嗽消失时间均短于对照组,差异均有统计学意义(P<0.05)。观察组复发率为5.3%(2/38),对照组复发率为23.3%(10/30),2组比较,差异有统计学意义(P<0.05)。结论:沙参麦冬汤加减联合西药治疗小儿顽固性咳嗽肺阴亏虚证,比单独使用西药治疗效果更好,能快速缓解症状,减少复发。

Objective：To observe the clinical effect of modified Shashen Maidong tang combined with western medicine for intractable cough in children with deficiency of lung yin syndrome. Methods：Selected 80 cases of children with intractable cough with deficiency of lung yin syndrome in our hospital, and divided them randomly into the control group and the observation group,40 cases in each group. The control group was given western medicine such as anti-inflammatory drugs,expectorants, antitussives and antiasthmatics for treatment, while the observation group additionally received modified Shashen Maidong tang based on the treatment of the control group. After treatment, compared the clinical effect of both groups. Then recorded the onset time of medicine and disappearance time of cough in both groups before and after treatment,and calculated the recurrence rate. Results：The cure rate and total effective rate in the observation group were70.0% and 95.0% respectively,while those in the control group were 22.5% and 75.0% respectively. The comparisons of the cure rate and total effective rate between the two groups respectively showed significance in differences（P〈0.01,P〈0.05）.The onset time of medicine and disappearance time of cough in the observation group were both shorter than those in the control group,differences being significant（P〈0.05）. The recurrence rate was 5.3%（2/38） in the observation group and 23.3%（10/30） in the control group,the difference being significant（P〈0.05）. Conclusion：When treating intractable cough in children with deficiency of lung yin syndrome,the therapy of modified Shashen Maidong tang combined with western medicine has better effect than the therapy of pure western medicine,for it can rapidly relieve symptoms and reduce recurrence.