基于“脾主思”理论观察脑源性神经因子、5-羟色胺、多巴胺、去甲肾上腺素在胃食管反流病中的表达意义

Based on the theory of “spleen governing thinking” to observe the expression of brain-derived neurotrophic factor,5-HT,dopamine and norepinephrine in gastroesophageal reflux disease

[目的]基于"脾主思"理论指导下探索脑源性神经因子(BDNF)、5-羟色胺(5-HT)、多巴胺(DA)、去甲肾上腺素(NE)在胃食管反流病(GERD)中的表达情况。[方法]以随机数字表法收集GERD患者80例为观察组,健康人群80例为对照组,通过观察患者情绪、睡眠、饮食情况、汉密尔顿抑郁量表(HAMD)与日常生活能力量表(ADL)积分、BDNF、5-HT、DA、NE表达水平来评价"脾主思"理论在GERD中的意义。[结果](1)GERD组患者睡眠、情绪异常高于对照组,饮食较对照组相比减少(P<0.05)。(2)GERD组HAMD量表积分明显高于对照组,而ADL积分低于对照组(P<0.05)。(3)GERD组患者BDNF、5-HT、DA、NE水平均低于对照组(P<0.05)。[结论]GERD患者存在精神及生活状态异常可能与BDNF、5-HT、DA、NE低水平表达有关,为"脾主思"理论提供客观依据,可作为评价GERD患者疗效及预后的指标。

[Objective]Based on the theory of＂spleen governing thinking＂to explore the expression of brain-derived neurotrophic factor,5-dopamine and norepinephrine in gastroesophageal reflux disease.[Methods]80 cases of GERD patients were collected as the observation group and 80 cases of healthy people as the control group randomly.Through the observation of patients with mood,sleep,diet,Hamilton Depression Scale（HAMD）and ADL（Activities of daily living）scale points,BDNF,5-HT,DA and NE expression to evaluate the＂spleen thinking＂theory significance in GERD.[Results]（1）GERD group patients sleep abnormalities,emotional abnormalities were higher than the control group,diet compared to the control group decreased（P0.05）.（2）The scores of HAMD scale in group GERD were significantly higher than those in control group,while ADL integral score was lower than that in control group（P0.05）.（3）The levels of BDNF,5-HT,DA and NE in GERD group were lower than those in control group（P0.05）.[Conclusion]GERD patients with abnormal mental and living status may be related to low levels of BDNF,5-HT,DA and NE,and provide an objective basis for the theory of＂spleen governing thinking＂,which can be used as an index to evaluate the efficacy and prognosis of GERD patients.