摘要
蛋白质是一种优良的药物载体,具有良好的生物相容性、生物可降解性、极低的细胞毒性。基于蛋白质的纳米载药系统可显著改善药物的理化性质,提高药物稳定性,增强药物口服吸收效果,达到增效减毒的目的。综述了基于蛋白质的口服纳米载药系统研究进展,并指出了该领域未来的发展方向。
Protein is considered as an excellent drug carrier with good biocompatibility, biodegradability,and low cytotoxicity. Protein-based nanoparticle drug delivery system can significantly improve the physico chemical properties of drugs, improve drug stability, and enhance oral absorption effect so as to attain the goal of increas- ing effect and decreasing toxicity. We review the research progress in protein-based nanoparticle drug delivery system for oral administration and point out the future direction of this field.
出处
《化学与生物工程》
CAS
2018年第3期1-5,共5页
Chemistry & Bioengineering
基金
国家自然科学基金项目(81503027)
中国药科大学药学基地科研训练及科研能力提高项目(J1310032)
关键词
蛋白质
口服给药
纳米栽药系统
protein
oral administration
nanoparticle drug delivery system
