聚乙二醇单甲醚接枝改性壳聚糖的研究

Graft Modification of Chitosan by Polyethylene Glycol Monomethyl Ether

采用十二烷基硫酸钠(SDS)对壳聚糖(CS)链上的氨基进行保护,得到中间产物壳聚糖-十二烷基硫酸钠复合物(CS-SDS)。以六亚甲基二异氰酸酯(HDI)为偶联剂活化聚乙二醇单甲醚(mPEG)得mPEG-NCO。将mPEG-NCO接枝到CS-SDS上,脱除壳聚糖氨基保护,制得CS与mPEG的接枝共聚物CS-g-mPEG,并采用FTIR、1 HNMR、GPC、XRD、TG-DTG等方法对产物结构进行表征。XRD分析表明,CS-g-mPEG结晶度降低,溶解性提高;热重分析表明,CSg-mPEG降解温度升高,热稳定性提高;CS-g-mPEG的摩尔接枝率达到28.55%。

We used sodium dodecyl sulfate（SDS） to protect the amino group on chitosan（CS） chain,and ob- tained the intermediate product of chitosan-sodium dodecyl sulfate complex（CS-SDS）. Furthermore, using 1,6- hexamethylene diisocyanate（HDI） as a coupling agent,we abtained activated mPEG-NCO,which grafted onto CS-SDS, removed chitosan amino protection, and synthesized graft copolymer CS-g-mPEG. Furthermore, we characterized the structure of the product by FTIR,1HNMR, GPC, XRD, and TG-DTG. XRD analysis results show that crystallinity of CS-g-rnPEG decreases,and the solubility improves. Thermogravimetry analysis results show that the degradation temperature of CS-g-mPEG increases, and the thermal stability improves. The molar grafting rate of CS-g-mPEG reaches 28.55 %.