心脏病患者行非心脏手术麻醉恢复期肌松拮抗剂使用安全性评估

Safety assessment of muscle relaxation antagonist in patients with heart disease undergoing non cardiac surgery during recovery period of anesthesia

目的:探讨心脏病患者接受全麻非心脏手术后,新斯的明康维库溴铵在麻醉恢复室中使用的有效性及安全性。方法:收治心脏病接受全麻非心脏手术患者183例,随机分为3组。对照组为A组,不使用肌松拮抗药物;M组与N组分别为新斯的明单次给药组和新斯的明分次给药组。比较3组的恢复情况。结果:与A组相比,M组和N组的拔管时间显著缩短,3组低血压、高血压、再插管率、心律失常、谵妄及恶心、呕吐差异无统计学意义(P>0.05)。结论:心脏病患者行非心脏手术麻醉恢复期采用肌松拮抗剂能够缩短拔管时间,促进肌肉收缩功能恢复,无不良反应。

Objective：To explore the effectiveness and safety of use of neostigmine vecuronium bromide in anesthesia recovery room for patients with heart disease undergoing non cardiac surgery by general anesthesia.Methods：183 patients with heart disease undergoing non cardiac surgery by general anesthesia were selected.They were randomly divided into 3 groups,the A group was the control group,and no muscle relaxant was used.The observation group was divided into the M group and the N group,and they were the neostigmine single dose administration group and the neostigmine fractionated drug delivery group.We compared the recovery of the 3 groups.Results：Compared with the A group,the extubation time in the M group and the N group was significantly shortened,and there was no significant difference in hypotension,hypertension,re-intubation rate,arrhythmia,delirium and nausea and vomiting of the three groups（P〉0.05）.Conclusion：The application of muscle relaxation antagonist in patients with heart disease undergoing non cardiac surgery during recovery period of anesthesia can shorten the time of extubation,promote the recovery of muscle contractile function,and there was no adverse reactions.