阿托品预防PCI术中心肌缺血再灌注损伤的效果观察

Effect observation of atropine in preventing myocardial ischemia reperfusion injury in percutaneous coronary intervention

目的探讨阿托品对经皮冠状动脉介入治疗(PCI)中心肌缺血再灌注损伤(MIRI)的预防作用。方法将我院急诊经皮冠状动脉造影后确诊为急性心肌梗死的106例患者按不同治疗方法分为观察组(46例)和对照组(60例)。两组患者均给予支架植入手术,观察组在冠状动脉球囊扩张前给予阿托品静脉注射。比较两组患者在血流再通后出现MIRI事件的阳性率。结果观察组心动过缓、低血压、恶心呕吐等MIRI事件阳性率显著低于对照组,差异具有统计学意义(P<0.05)。观察组无阿托品毒副作用出现。结论阿托品能够显著降低PCI术中MIRI临床事件阳性率,预防效果良好。

Objective To explore the preventive effect of atropine on myocardial ischemia reperfusion injury（MIRI） in percutaneous coronary intervention（PCI）. Methods According to different treatment methods, 106 patients who were diagnosed as acute myocardial infarction after percutaneous coronary angiography in our hospital were divided into observation group（46 cases） and control group（60 cases）. Both groups were given stent-graft surgery. The observation group received atropine intravenously before coronary artery balloon dilatation. The positive rates of MIRI events were compared between the two groups after recanalization. Results The positive rate of MIRI events in the observation group was significantly lower than that in the control group, such as bradycardia, hypotension, nausea and vomiting, the difference was statistically significant（P〈0.05）. No side effects of atropine in the observation group appeared. Conclusion Atropine can significantly reduce the positive events rate of MIRI events in PCI, which has a good preventive effect.