奥美拉唑与兰索拉唑分别联合抗生素治疗酒精型消化溃疡的疗效分析

Effect of omeprazole and lansoprazole respectively combined with antibiotics on alcohol-type peptic ulcer

目的观察酒精型消化溃疡应用抗生素分别联合奥美拉唑、兰索拉唑治疗的疗效及安全性、预后复发情况。方法回顾性分析2014年1月至2017年1月在我院治疗的128例酒精型消化溃疡患者的临床资料,按治疗方案不同分对照组和观察组,各64例。所有患者均行阿莫西林+克拉霉素+维U颠茄铝胶囊等常规方案治疗,在常规治疗基础上对照组予奥美拉唑治疗,观察组予兰索拉唑治疗。比较两组患者的疗效。结果观察组患者的治疗总有效率高于对照组(P<0.05);观察组不良反应总发生率低于对照组(P<0.05);观察组Hp根除率高于对照组(P<0.05);观察组6个月随访溃疡复发率低于对照组(P<0.05)。结论酒精型消化溃疡在抗生素治疗基础上联合兰索拉唑治疗可显著提高临床疗效。

Objective To observe the curative effect, safety and prognosis recurrence of antibiotics combined with omeprazole and lansoprazole respectively on alcohol-type peptic ulcer. Methods The clinical data of 128 patients with alcohol-type peptic ulcer who received treatment in our hospital from January 2014 to January 2017 were selected, and were divided into control group and observation group according to the different treatment options applied, with 64 patients in each group. All patients were treated with amoxicillin ＋clarithromycin ＋Victoria U belladonna aluminum capsule antibiotics and other conventional regimens, on this basis, the control group was treated with omeprazole and the observation group was treated with lansoprazole. The efficacy of the two groups were compared. Results The total effective rate in the observation group was higher than that in the control group（P〈0.05）; the total incidence of adverse reactions in the observation group was lower than that in the control group（P〈0.05）; the eradication rate of Hp in the observation group was higher than that in the control group（P〈0.05）; the follow-up 6 months ulcer recurrence rate in the observation group was lower than that in the control group（P 0.05）. Conclusion For patients with alcohol-type peptic ulcer, antibiotics combined with lansoprazole can significantly improve the clinical efficacy.