硝苯地平联合卡托普利治疗妊娠高血压综合征的效果分析

Effect of nifedipine combined with captopril in the treatment of pregnancy-induced hypertension syndrome

目的探究硝苯地平联合卡托普利治疗妊娠高血压综合征的效果,为产科治疗工作的开展提供有效参考。方法选取我院2016年1月至2017年2月收治的100例妊娠高血压综合征患者作为研究对象,根据治疗方案不同分为对照组和试验组,各50例。对照组患者接受硝苯地平治疗,试验组患者接受硝苯地平+卡托普利治疗。比较两组患者的治疗效果、治疗前后血压、分娩结局、产后出血发生率及新生儿并发症发生率。结果试验组患者治疗总有效率为98.00%,明显高于对照组患者的78.00%(P<0.05)。治疗后,两组的舒张压、收缩压均明显下降,且试验组明显低于对照组,差异具有统计学意义(P<0.05)。试验组患者剖宫产率低于对照组,顺产率高于对照组,差异具有统计学意义(P<0.05)。试验组患者产后出血率低于对照组(P<0.05)。试验组新生儿窒息、早产、胎儿窘迫、胎盘早剥等并发症发生率均低于对照组,差异均具有统计学意义(P<0.05)。结论卡托普利+硝苯地平治疗妊娠高血压综合征的疗效显著,能显著改善患者血压水平,顺产率高,新生儿并发症少。

Objective To explore the effect of nifedipine combined with captopril in the treatment of pregnancy-induced hypertension syndrome, and to provide an effective reference for the development of obstetric treatment. Methods A total of100 patients with pregnancy-induced hypertension syndrome admitted in our hospital from January 2016 to February 2017 were selected as the study objects, and randomly divided into control group and experimental group according to the different treatment methods, with 50 cases in each group. Patients in the control group received nifedipine, and patients in the experimental group received nifedipine ＋captopril. The treatment effect, blood pressure before and after treatment,delivery outcomes, postpartum hemorrhage rates and neonatal complications rates were compared between the two groups.Results The total effective rate of the experimental group was 98.00%, which was significantly higher than 78.00% of the control group（P 0.05）. After treatment, diastolic blood pressure and systolic blood pressure of both groups significantly decreased, and those of the experimental group were significantly lower than the control group, the differences were statistically significant（P〈0.05）. The rate of cesarean section in the experimental group was lower than that in the control group, and the yield rate was higher than that in the control group（P 0.05）. The postpartum hemorrhage rate in the experimental group was lower than that in the control group（P〈0.05）. The incidence of neonatal asphyxia, premature labor,fetal distress and placental abruption in the experimental group were lower than those in the control group, the differences were statistically significant（P 0.05）. Conclusion Captopril ＋nifedipine has a significant effect in the treatment of pregnancy-induced hypertension syndrome, which can significantly improve the patients＇ blood pressure level, with high rate of normal labor and fewer neonatal complications.