平肝化浊浴足方治疗高血压病的疗效及对血脂的影响

The Influence of Pinggan Huazhuo Yuzu Decoction on Blood Lipid in Hypertension Patients

目的观察平肝化浊浴足方治疗高血压病的疗效及对血脂的影响。方法选取上海市第六人民医院金山分院中医内科门诊高血压病证(肝火亢盛夹痰浊型)病人60例,随机分为治疗组和对照组,对照组口服左旋氨氯地平片和辛伐他汀片,治疗组在对照组的基础上加用平肝化浊浴足方浴足,每晚1次,共治疗6个月。观察两组治疗前后血脂变化,比较两组降压疗效。结果两组治疗后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)较治疗前明显降低,高密度脂蛋白胆固醇(HDL-C)较治疗前明显升高,差异有统计学意义(P<0.05);与对照组治疗后比较,治疗组TC、TG、LDL-C明显降低(P<0.05),HDL-C差异无统计学意义(P>0.05)。治疗组总有效率为76.67%,高于对照组的66.67%,差异有统计学意义(P<0.05)。结论平肝化浊浴足方降低高血压病人血压的同时,能更好地调节血脂。

Objective To observe the effect of Pinggan Huazhuo Yuzu decoction（PHYD）on blood lipid in patients with essential hypertension（EH）.Methods Sixty patients with EH and syndrome of hyperactivity of liver-fire and phlegm-turbid from Jinshan Branch of Shanghai Sixth People’s Hospital were randomly divided into two groups：control group treated with levamlodipine besylate and simvastatin,and treatment group treated with levamlodipine besylate,simvastatin and PHYD for 6 months.Blood pressure and blood lipid were observed before and after treatment.Results The levels of total cholesterol（TC）,triglycerides（TG）,low-density lipoprotein cholesterol（LDL-C）were decreased in two groups after treatment while high-density lipoprotein cholesterol（HDL-C）levels were increased（P 〈0.05）.The levels of TC,TG,LDL-C were lower in treatment group than that in control group（P 〈0.05）.The total clinical effective rate was higher in treatment group than that in control group（76.67% vs 66.67%,P 〈0.05）.Conclusion PHYD can reduce blood pressure and regulate blood lipid in patients with EH.