NADPH氧化酶介导的氧化应激在细胞骨架相关调控活动中的作用

NOX-Mediated Oxidation in the Regulation of Cytoskeleton-Related Activities

细胞骨架是细胞赖以生存的内在支撑结构,主要包括微管、中间丝状体及微丝。细胞骨架上游Rho GTP酶的活化、细胞骨架重塑过程和细胞骨架参与的相关细胞功能活动(如迁移和黏附等)均与胞内氧化应激压力有关。NADPH氧化酶(NADPH oxidase,NOX)介导的氧化应激已成为细胞骨架相关活动的重要影响因素之一。因此,认识NOX介导的氧化应激对了解细胞骨架调控相关活动至关重要,为今后深入研究细胞骨架相关疾病奠定理论基础。

Cytoskeleton is the internal support structure for cells to survive, mainly including microtubules, intermediate filaments and microfilaments. Studies have confirmed that the activation of cytoskeleton upstream Rho GTPase, cytoskeleton self-remodeling and cytoskeletal related cell functions such as migration, adhesion and other cell physiological activities are related to intracellular oxidative stress. In recent years, NOX-induced oxidative stress has become one of the important factors affecting cytoskeleton-related activities. This makes it essential for us to understand NOX-induced oxidative stress and cytoskeletal regulation and lay a solid foundation for the study of related diseases.