Alpha4对蛋白磷酸酶2A的调节作用研究进展

Progress on Regulation of Protein Phosphatese 2A by Alpha4

蛋白磷酸酶2A(protein phosphatase 2A,PP2A)是真核细胞内重要的丝氨酸/苏氨酸蛋白磷酸酶,调控着许多重要的细胞生命活动。近年来,随着PP2A逐渐被认为是一个必要的肿瘤抑制因子,alpha4作为其重要的一个调节蛋白也受到了广泛关注。Alpha4能对PP2A进行多种调节,包括调节PP2A的酶活性和促进PP2A核心酶的组装。在转化细胞和肿瘤细胞中还发现了alpha4的异常表达,这表明alpha4具有促进肿瘤发生的功能。该文就哺乳动物中alpha4对PP2A的调节机理作一综述,这将有助于我们更好地理解PP2A和alpha4的作用机制及该机制对肿瘤的治疗意义。

Protein phosphatase 2 A（PP2A）, as one of the most important serine/threonine phosphatases in eukaryotic cells, plays crucial roles in the process of cell cycle and signaling transduction. Numerous studies indicate that PP2A acts as a tumor suppressor and, therefore, the PP2A binding protein alpha4 starts being given more attention. Alpha4 has been reported to interact with PP2A, as it maintains the stability of PP2A activity and manages core enzyme assembly of PP2A. Moreover, alpha4 mutants are discovered in carcinogen-transformed human cells and primary human cancer cells, which demonstrate the character of carcinogenesis of alpha4. In this review, a brief summary of advances in studies of regulation of PP2A by alpha4 is given, which might help to give a further comprehension of PP2A and alpha4 in basic and clinical investigations for cancer.