p38丝裂原活化蛋白激酶信号通路在脓毒症器官功能障碍中的作用

The Role of p38 Mitogen-Activated Protein Kinase Signaling Pathway in the Sepsis with Multiple Organ Dysfunction Syndrome

p38丝裂原活化蛋白激酶(p38 mitogen-activated protein kinase,p38 MAPK)信号通路是多种细胞信号转导、疾病的发生发展中的重要信号通路,在脓毒症的病情进展中发挥重要作用,是导致器官功能障碍发生的关键通路之一。该文就p38 MAPK在炎症介质的释放、氧化应激损伤、细胞凋亡、钙离子超载等方面的作用进行综述,阐述了p38 MAPK在脓毒症器官功能障碍方面的作用及其近年来的研究进展。

p38 mitogen-activated protein kinase（p38 MAPK） signaling pathway is an important signal pathway in the conduction process of cell signaling and the occurrence and development of disease. Especially, p38 MAPK plays an crucial role in the disease progression of sepsis and it is one of the key links leading to organ dysfunction. In this paper, the role of p38 MAPK in the release of inflammatory mediators, oxidative stress injury, apoptosis and calcium overload were reviewed, meanwhile, the role of p38 MAPK in organ dysfunction of sepsis and the recent research progress were also discussed.