碳酸锂致味觉丧失

Ageustia due to lithium carbonate

1例53岁女性患者因双相情感障碍遵医嘱口服碳酸锂，首剂0.25 g、2次/d，第4天增至0.75 g/d，第7天增至1.0 g/d。用药第8天，患者出现味觉丧失。停用碳酸锂，遵医嘱改服丙戊酸钠缓释片0.5 g、2次/d，10 d后患者味觉丧失减轻，32 d后味觉恢复正常。

A 53-year-old female patient with bipolar disorder received lithium carbonate 0.25 g twice daily for the first time following the doctor′s advice. On day 4, the dosage of lithium carbonate was increased to 0.75 g once daily. On day 7, the dosage was increased to 1.0 g once daily. On day 8 of administration, the patient developed the symptom of ageusia. Lithium carbonate was withdrawn. The patient′s treatment was changed to sodium valproate extentab 0.5 g twice daily according to the doctor′s order. Ten days later, the patient′s symptom of ageusia was alleviated. Thirty-two days later, her gustatory sense returned to normal.