2型糖尿病患者血清C1q/肿瘤坏死因子相关蛋白9水平与颈动脉粥样硬化的相关性被引量：6

下载PDF

导出

摘要目的探讨2型糖尿病(T2DM)患者血清脂肪细胞因子C1q/肿瘤坏死因子相关蛋白(CTRP)9水平与颈动脉粥样硬化(CAS)的相关性。方法选择新诊断的T2DM患者93例,根据有无CAS分为合并CAS组(C组,46例),不合并CAS组(B组,47例),选择健康体检者为对照组(A组,49例);采用酶联免疫吸附法(ELISA)测定空腹血清CTRP9水平。结果 (1)3组血清CTRP9水平依次为:A组[(151.2±45.74)pg/ml]>B组[(136.2±34.55)]pg/ml>C组[(123.2±32.13)pg/ml],差异均有统计学意义(P<0.05或P<0.01)。(2)CTRP9与空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、体重指数(BMI)、三酰甘油(TG)、肿瘤坏死因子(TNF)-α、颈动脉内中膜厚度(IMT)呈负相关(r=-0.595、-0.615、-0.512、-0.638、-0.592、-0.526,-0.598、-0.579,P<0.05或P<0.01),与脂联素(APN)、超氧化物歧化酶(SOD)正相关(r=0.512、0.523,P<0.05)。(3)多元回归分析显示:HOMA-IR、CTRP9、TNF-α是T2DM患者IMT增厚的独立影响因素。结论血清CTRP9在T2DM合并CAS发生中起重要作用。

作者吴萍刘云涛简磊

机构地区三峡大学附属仁和医院院感科三峡大学附属仁和医院内分泌科

出处《中国老年学杂志》 CAS 北大核心 2018年第5期1070-1072,共3页 Chinese Journal of Gerontology

关键词 C1q/肿瘤坏死因子相关蛋白9 2型糖尿病颈动脉粥样硬化

分类号 R587 [医药卫生—内分泌]

引文网络
相关文献

参考文献1

1刘天骄,郭媛,李婷婷,张建宁,李俊,张鹏.血清CTRP9、APN水平与急性冠脉综合征的相关性[J].山东大学学报（医学版）,2014,52(9):58-62. 被引量：8

二级参考文献16

1Su H, Yuan Y, Wang X M, et al. Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFo-initiated oxidative signaling contrib- utes to exacerbated cardiac injury in diabetic mice [J]. J I- Basic Res Cardiol, 2013, 108(1) : 1-12.
2Kojima S, Kojima S, Maruyoshi H, et al. Hypercholes- terolemia and hypoadiponectinemia are associated with necrotic core-rich coronary plaque [ J ]. Int J Cardiol, 2011, 147(3) : 371-376.
3Sawada T, Shite J, Shinke T, et al. Low plasma adi- ponectin levels are associated with presence of thin-cap fi- broatheroma in men with stable coronary artery disease [J]. Int J Cardiol, 2010, 142(3) : 250-256.
4Iwata A, Miura S, Mori K, et al. Associations between metabolic factors and coronary plaque growth or arterial remodeling as assessed by intravascular ultrasound in pa- tients with stable angina [ J ]. Hypertens Res, 2008, 31 (10): 1879-1886.
5Li L, Cai X J, Feng M, et al. Effect of adiponectin over- expression on stability of preexisting plaques by inducing prolyl-4-hydroxylase expression [ J ]. Circ J, 2010, 74 (3) : 552-559.
6Margaritis M, Antonopoulos A S, Digby J, et al. Interac- tions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of en- dothelial nitric oxide synthase function in human vessels [ J ]. Circulation, 2013, 127 (22) : 2209-2221.
7Okamoto Y, Ishii S, Croce K, et al. Adiponectin inhibitsmacrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques [ J ]. Atherosclerosis, 2012, 226(2013) : 373-377.
8Wong G W, Krawczyk S A, Kitidis-Mitrokostas C, et al. Identification and characterization of CTRP9, a novel se- creted glycoprotein, from adipose tissue that reduces ser- um glucose in mice and forms heterotrimers with adipone- ctin[J]. FASEB J, 2009, 23(1): 241-258.
9Peterson J M, Wei Z, Wong G W. CTRP8 and CTRPgB are novel proteins that hetero-oligomerize with C1 q/TNF family members [ J ]. Biochem Biophys Res Commun, 2009, 388(2): 360-365.
10Sun Y, Yi W, Yuan Y, et al. Clq/tumor necrosis fac- tor-related protein-9, a novel adipocyte-derived cyto- kine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation[J].Circula- tion, 2013, 128(26) : 113-120.