间充质干细胞在ARDS治疗中的临床应用

Application of mesenchymal stem cell in the treatment of acute respiratory distress syndrome

急性呼吸窘迫综合征（ARDS）是严重感染、创伤等因素导致的严重急性呼吸衰竭，病死率很高。ARDS致病机制较复杂，过度炎症反应在其中起到重要作用。间充质干细胞（MSC）是干细胞家族的重要成员，具有显著的免疫调节作用，对自身免疫性疾病、移植物抗宿主病等具有潜在的治疗效果。近年来的基础研究显示，MSC对ARDS治疗有潜在价值。本文简要介绍了MSC的相关基础研究结果，并总结了MSC治疗ARDS的基础和临床研究，对临床应用MSC治疗ARDS需要解决的问题进行了简要探讨，旨在为临床治疗ARDS提供新的思路。

Acute respiratory distress syndrome （ARDS） is severe acute respiratory failure caused by severe infections, trauma or others, and with high mortality rate. The pathogenesis of ARDS is complicated, but the uncontrolled excessive inflammatory response is identified as one of the main causes. Mesenchymal stem cells （MSCs） have the ability to regulate immune responses, and many researches showed that MSCs had potential therapeutic effects on autoimmune diseases and graft versus host diseases. Recently, basic researches showed that MSCs could treat ARDS and many scientists paid attention to the therapeutic use of MSC in the treatment of ARDS. This paper summarized the basic and clinical results obtained in application of MSC in treatment of ARDS, and discussed the problems needed to be resolved in the further studies in order to provide new ideas for clinical treatment of ARDS.