尿源性干细胞及其在口腔医学组织工程中的应用前景

Urine-derived Stem Cells and Their Potential Applications in Oral Maxillofacial Tissue Engineering and Regeneration.

尿源性干细胞(Urine-derived stem cells,USCs)是存在于尿液中,具有高度增殖性、自我更新能力、多向分化潜能及旁分泌特性的一种成体干细胞。作为一种新型的细胞来源,USCs储备丰富,取材容易,具有极佳的可行性和安全性。USCs利用其多向分化潜能和旁分泌特性参与组织再生的研究,已在临床前动物模型中取得一定成果。其研究成果均展示了USCs在口腔组织工程中的应用潜能。本文就其应用前景作一综述。

Urine-derived stem cells（USCs）are novel adult stem cells existing in urine which possesses highly expandability,self-renewal capacity,paracrine properties,and multi-differentiation potential.In tissue regeneration,as a new source of cells,the USCs have excellent feasibility and safety.Most importantly,the body has a substantial source of USCs,which can be harvested easily in a non-invasive manner,regardless of the age,sex,and health condition of patients.USCs have been used in preclinical animal models to repair or regenerate tissue,employing either trans-differentiation or paracrine effects to stimulate endogenous cells participating in tissue regeneration.The potential application of USCs in oral maxillofacial tissue regeneration is reviewed in this paper.