3486例血液病住院患者并发血栓栓塞的临床研究

The clinical study of thrombosis in 3 486 in-patients with hematologic diseases

目的:观察血液病患者并发血栓情况,分析高危因素,为今后临床预防、治疗血栓栓塞提供依据和指导。方法:回顾性分析血液科住院患者3 486例,记录其中发生血栓的患者情况,并加以统计。结果:总体血栓发生率为1.49%,恶性血液病发生率2.07%,占全部血栓的86.54%;非恶性血液病发生率0.53%,占全部血栓的13.46%,二者比较差异有统计学意义(P<0.001)。高龄、深静脉置管、输血、糖皮质激素、化疗、血小板计数减少为血栓栓塞的高危因素(P<0.05)。结论:恶性血液病并发血栓栓塞的风险明显高于非恶性血液病,血液病患者血小板计数减少血栓风险更高。

Objective：To study the incidence of thrombosis in hematologic patients and analyze the risk factors of thrombosis,in order to provide evidence and guidance for prevention and treatment of thrombosis.Method：A total of 3486 in-patients with hematologic diseases were enrolled.We recorded and analyzed clinical biological characteristics and related risk factors of concomitant thrombosis.Result：The overall incidence of thrombosis was1.49%.The incidence of malignant hematologic diseases was 2.07%,which accounted for 86.54% of the total thrombosis.The non-malignant hematologic diseases was 0.53%,which accounted for 13.46% of the total thrombosis.There were significant differences between two groups（P〈0.001）.Advanced age,deep vein catheterization,blood transfusion,glucocorticoids,chemotherapy and decreased platelet count were high risk factors for thrombosis（P〈0.05）.Conclusion：The risk of thrombosis in malignant hematologic diseases is significantly higher than that of non-malignant hematologic diseases.Thrombocytopenia is associated with higher risk of thrombosis in patients with hematologic diseases.