髓系来源的抑制性细胞在母-胎界面的研究进展

Myeloid derived suppressor cells at the maternal-fetal interface

髓系来源的抑制性细胞(myeloid derived suppressor cells,MDSCs)是一类具有显著抑制T细胞功能的异质性细胞群体,能够促进机体免疫耐受形成。在妊娠建立过程中,母体免疫系统要对含有父系抗原的胎儿具有足够的免疫耐受,具有免疫抑制特性的细胞以及细胞因子在母-胎界面聚集是母-胎免疫耐受形成的机制之一。近年来,有研究表明MDSCs在母-胎界面聚集,促进母-胎免疫耐受的形成。本文就MDSCs的免疫抑制特性及其在妊娠中的研究进展作一综述。

Myeloid-derived suppressor cells（MDSCs） are a heterogeneous group of myeloid cells that suppress immune responses through multiple mechanisms promoting the immune tolerance formation. The maintenance and establishment of normal pregnancy need enough maternal immune tolerance to fetus. Recent data have revealed that a large number of MDSCs accumulate at the maternal-fetal interface and promote the establishment of immune tolerance. In this review, we will focus on the mechanisms that regulate the expansion and function of MDSCs. In addition, meaningful questions that need further investigation and the various and potential roles of MDSCs at the maternal-fetal interface will be discussed.