摘要
胚胎着床涉及到胚胎和子宫间复杂的关系,是胚胎能否继续发育的重要环节。胚胎发育到囊胚阶段以及子宫内膜同步分化到容受状态是成功着床的关键。着床过程涉及到许多信号通路分子的相互作用,但是其中同步胚胎和子宫状态的调控网络仍有很多谜题未解开。本文总结了目前对于着床的分子调控以及在这个领域中的研究进展,对着床机制的了解有助于阐明女性不明原因的不孕症并且帮助提高胚胎着床率和妊娠率。
Embryo implantation involves complex contact between embryo and endometrium cells, which determines the following development of embryo. Synchronization of blastocyst activation and endometrial receptivity is the key process for implantation. This process involves signaling pathways regulating the synchronization together with many unknown questions. This review summarizes the present research status of exploring implantation pathways. To elucidate the mechanisms involving embryo implantation not only helps illuminate the unknown infertility in women but also may improve the implantation rate and even pregnancy rate.
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2018年第1期76-82,共7页
Chinese Journal of Reproduction and Contraception
基金
国家自然科学基金(重点项目)(81430026)
上海市科委基础研究领域项目(16JC1404700)
关键词
胚胎着床
子宫内膜容受性
囊胚激活
窗口期
Embryo implantation
Endometrial receptivity
Blastocyst activation
Window ofimplantation
