醒脑静注射液治疗老年脑梗死的临床疗效评价

Evaluation of clinical efficacy of Xingnaojing Injection in treatment of cerebral inforction in the elderly

目的探讨醒脑静注射液对老年脑梗死患者的临床疗效及脑血流动力学变化的影响。方法选取郑州大学第二附属医院2016-01—2017-01收治的124例老年脑梗死患者进行研究,将其根据随机双盲法分为对照组和观察组,每组62例;对照组采用临床常规治疗,观察组在对照组的基础上另给予醒脑静注射液治疗,对比观察2组临床疗效和脑血流动力学改变情况。结果治疗后观察组临床治疗总有效率为87.10%,显著高于对照组的62.90%,2组差异有统计学意义(χ2=9.68,P<0.05),且观察组患者治疗后1个疗程、2个疗程、3个疗程后的神经功能缺损评分(NIHSS评分)情况、双侧大脑中动脉峰流速(Vp)及平均流速(Vm)均显著优于对照组,2组相比差异有统计学意义(P<0.05)。结论醒脑静注射液治疗老年脑梗死可有效提高临床疗效评价,改善患者脑部血流动力学,具有较高的临床使用价值,值得推广。

Objective To investigate the clinical effect of Xingnaoiing injection on selaile cerebral infarction and its effect on cerebral hemodynamies in patients. Methods A total of 124 patients with cerebral infarction were enrolled from January 2001 to January 2017. They were divided into control group and observation group according to raiadomized double-blind method. 62 pa tients in each group. Clinical group were treated with conventional therapy,and the observation group were treated with Xingnao jing injection on the basis of the control group. The clinical treatment effect and cerebral hemodynamic changes were observed and compared between the two groups. Results The total effective rate of clinical treatment was 87.10% in the observation group af- ter treatment, which was significantly higher than that of the control group （62.90 %, x^2= 9.68, P〈0.05）. The NIHSS score, l he Vpand mean velocity （Vm） in the observation group were significantly better than those in the control group after three courses of treatment （P〈0.05）. Conclusion Xingnaojing injection can effectively improve the clinical treatment efficiency and brain hemodynamic changes in elderly patients with cerebral infarction,has a high clinical value and is worthy of clinical promotion.