女性帕金森病患者血清胱抑素C水平与帕金森病分级的关系

The relationship between Cystatin C and the severity of Parkinson's disease in female

目的分析女性帕金森病患者血清胱抑素C水平,探讨血清胱抑素C水平与女性帕金森病的严重程度及发生睡眠呼吸暂停低通气综合征的关系。方法选取郑州市中心医院诊断为帕金森病的女性患者40例,以我院同期体检科随机选取的年龄、性别、体质量匹配的40名健康体检人群为正常对照组,检测血清胱抑素C,并对不同组的血清胱抑素C进行对比分析。结果女性帕金森病患者血清胱抑素C水平显著高于正常对照组(P<0.01),女性帕金森病合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的患者血清胱抑素C水平显著高于不合并OSAHS的女性帕金森病患者(P<0.01),帕金森病患者Honehn&Yahr分级各组之间血清胱抑素C水平均差异无统计学意义(P>0.05)。结论女性帕金森病患者血清胱抑素C水平升高,女性帕金森病合并OSAHS的患者,血清胱抑素C高于不合并OSAHS的帕金森病患者,血清胱抑素C可能可以作为一个早期诊断帕金森病非运动障碍的指标。高胱抑素C水平可能与女性帕金森病的发病相关,但与帕金森病的严重程度无关。

Objective To analyze the relationship of serum cystatin C levels with disease severity and sleep apnea hypopnea syndrome in female patients with Parkinson＇s disease. Methods 40 cases of female patients diagnosed with Parkinson＇s disease in Zhengzhou Central Hospital were enrolled in this study, and 40 healthy people from the physical examination department were se lected as the control group. We tested and analyzed the serum cystatin C in different groups. Results The serum cystatin C levels in female patients with Parkinson＇s disease was significantly higher than that of normal control group （P〈0.01）. The serum cys- tatin C in female patients with Parkinson＇s disease and obstructive sleep apnea hypopnea syndrome （OSAHS） were significantly higher than those without OSAHS （P〈0.01）. The serum cystatin C in patients with different severity of Parkinson＇s disease clas sifted by Honehn^Yahr showed no significant difference （P〉0.05）. Conclusion The serum cystatin C in female patients with Parkinson＇s disease was elevated, the serum cystatin C was higher in female Parkinson＇s disease patients combined with OSAHS than those without OSAHS, serum cystatin C may be an early diagnostic marker of Parkinsoffs disease with non movement dis order. High levels of cystatin C may be associated with the onset of Parkinson＇s disease in female, but have no relationship with the severity of the disease.