期刊文献+

甲氨蝶呤治疗异位妊娠罕见急性中毒致外阴部溃疡伴感染的护理体会 被引量:2

下载PDF
导出
摘要 甲氨蝶呤是目前临床上针对异位妊娠使用频率较高的抗代谢药物,其作用机制是竞争性抑制二氢叶酸还原酶,阻断二氢叶酸还原成四氢叶酸,从而减少了DNA、RNA和蛋白质的生物合成,从而抑制滋养细胞增生,破坏绒毛,使胚胎组织坏死、脱落、吸收[1]。随着甲氨蝶呤在临床的广泛应用.
出处 《齐鲁护理杂志》 2018年第5期120-121,共2页 Journal of Qilu Nursing
  • 相关文献

参考文献2

二级参考文献26

  • 1谢幸,苟文丽.妇产科学[M].第8版.北京:人民卫生出版社,2013:258-264.
  • 2Tran H, Cheung C, Gill D, et al. Methotrexate-associated man- tle-cell lymphomain an elderly man with myasthenia gravis [J]. Nat Clin Pract Oncol,2008,5 (4) :234-238.
  • 3Agarwal A, Vijay K, Thamburaj K, et al. Transient leukoen- cephalopathy after intrathecal methotrexate mimicking stroke [ J. Emerg Radio1,2011,18 (4) :345-347.
  • 4Summers R J, Abramowsky CR, Cooper TM. Correlating Pa- thology With the Clinical Symptoms of Methotrexate-induced Leukoencephalopathy in a Child With Relapsed T-cell Acute Lymphoblastic Leukemia [ J ]. J Pediatr Hematol Oncol, 2012. [ Epub ahead of print].
  • 5Inaba H, Khan RB, Laningham FH, et al. Clinical and radio- logical characteristics of methotrexate-induced acute encepha- lopathy in pediatric patients with cancer[ J. Ann Oncol,2008, 19(1) :178-184.
  • 6Tufekci O, Yilmaz S, Karapinar TH,et al. A rare complication of intrathecal methotrexate in a child with acute lymphoblastic leukemia [ J ]. Pediatr Hematol Oncol, 2011,28 ( 6 ) : 517 -522.
  • 7Cheng KK. Association of plasma methotrexate, neutropenia, hepatic dysfunction, nausea/vomiting and oral mucositis in children with cancer[ J. Eur J Cancer Care(Engl) ,2008,17 (3) :306-311.
  • 8Hocaoglu N, Atilla R, Onen F, et al. Early-onset pancytopenia and skin ulcer following low-dose methotrexate therapy [ J ]. Hum Exp Toxico1,2008,27 (7) :585-589.
  • 9Csordas K, Eipel O, Hegyi M, et al. Pharmacokinetic analysis of high-dose methotrexate treatments in children with hemato- logic malignancies [ J]. Orv Heti1,2011,152 (40) : 1609-1617.
  • 10Barouta G, Karapetsa M, Kostopoulou E, et al. Oral tuberculo- sis in a patient with rheumatoid arthritis after long treatment with methotrexate and adalimumab [ J ]. J Clin Rheumatol, 2010,16(7) :330-331.

共引文献33

同被引文献17

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部