血清IgE水平与冠心病的相关性分析

Correlative Analysis of the Serum IgE Levels with Coronary Artery Disease

目的:探讨血清IgE水平与冠心病的相关性。方法:将我院收治的135例患者根据冠脉造影结果分为冠心病组(CHD)和非冠心病组(non-CHD),冠心病组根据临床症状分为稳定型心绞痛组(SAP)、不稳定型心绞痛组(UAP)和急性心肌梗死组(AMI),动脉堵塞程度用Gensini评分量化,采用SIMENS BNII全自动免疫散射比浊仪测定总IgE水平。比较CHD和non-CHD组患者及SAP、UAP和AMI组患者血清IgE水平的差异,并进一步分析血清IgE等级与冠心病Gensini积分的相关性。结果:non-CHD患者血清IgE水平(32.3(13.5,61)KU/L)明显低于CHD患者(69(26.4,169)KU/L)(P=0.001),UAP和AMI患者血清IgE水平(78.6(37.0,191.0)KU/L、118.5(75.3,148.1)KU/L)均显著高于SAP组(36.7(20.7,96.7)KU/L)(P=0.034和P=0.001),且多支血病变组患者血清IgE水平(67.2(30.9,249.0)KU/L)显著高于单支血管病变患者(34.6(18.1,59.0)KU/L)(P=0.039)。IgE水平根据四分位间距分为四个等级,随着IgE分级水平增加冠心病Gensini积分增加。结论:冠心病患者血清IgE水平升高,且与冠心病类型和血管堵塞程度都存在显著相关性,可能辅助冠心病的诊断及病情监测。

Objective： To explore the relationship between lgE levels in serum and coronary heart disease. Methods： All 135 en- rolled patients in our hospital were divided into the coronary heart disease （CHD） group and non-coronary heart disease （non-CHD） group according to the results of coronary angiography. The CHD group was subgrouped into stable angina pectoris （SAP） group, unsta- ble angina pectoris （UAP） group and acute myocardial infarction （AMI） group according to the clinical symptoms. The degree of arterial occlusion was quantified using the Gensini score. The total IgE level was measured by SIEMENS BNII automatic immuno scatter tur- bidimeter. The serum IgE levels between CHD and non-CHD group were compared, and a comparison of the IgE levels among SAP, UAP and AMI group was also carried out. Furthermore, the relationship of IgE ranges and Gensini score was analyzed. Results： The serum IgE level in non-CHD group （32.3 （13.5, 61） KU/L） was significantly lower than that of the CHD group （69 （26.4, 169） KU/L） （P=0.001）. And the serum IgE levels of UAP （78.6 （37.0, 191.0） KU/L） and AMI group （118.5 （75.3, 148.1） KU/L） were both significantly higher than that of the SAP group （36.7 （20.7, 96.7） KU/L） （P=0.034 and P=0.001）. Besides, we found that the serum IgE level of pa- tients with multi-vessel disease （67.2 （30.9, 249.0） KU/L） was significantly higher compared to that of patients with single-vessel disease （34.6 （18.1, 59.0） KU/L） （P=0.039）. Finally, Gensini score was increased with the increase of serum IgE level. Conclusions： Serum IgE level was increased in CHD patients compared with that in non-CHD ones. Moreover, serum IgE level was related to the state and severity of CHD, which may provide references for the diagnosis and monitoring of CHD.