苦参碱注射液对宫颈癌患者化疗的增敏作用及对T细胞亚群、CA125、IL-6的影响

Chemotherapy Sensitization Effect of Matrine Injection on Patients with Cervical Cancer and Influence on the T Cell Subsets, Serum CA125 and IL-6 Levels

目的:研究苦参碱注射液对宫颈癌患者化疗的增敏作用及对T细胞亚群、CA125、IL-6的影响。方法:选择2015年4月至2017年3月在我院进行宫颈癌治疗的76例患者,随机将其均分为观察组(59例)和对照组(59例),对照组患者给予化疗,而观察组则在对照组化疗的基础上增加苦参碱注射液进行治疗,记录并比较两组患者治疗前后T细胞亚群、CA125及IL-6水平的变化、肿瘤病灶面积的改善情况、临床疗效及不良反应的发生情况。结果:治疗后,观察组患者的肝肾功能损伤、骨髓抑制剂胃肠道反应等不良反应发生率、血清CA125及IL-6水平均明显低于对照组(P<0.05),而总有效率(81.58%)显著高于对照组(50.00%)(P<0.05),CD3^+、CD4^+及CD4/CD8^+水平也明显高于对照组(P<0.05),而观察组患者CD8^+水平则明显低于对照组(P<0.05)。结论:苦参碱注射液辅助宫颈癌化疗的增敏效果显著,能有效降低患者CA125及IL-6水平,显著改善机体T细胞免疫功能。

Objective： To study the chemotherapy sensitization effect ofmatrine injection on the cervical cancer patients and influ- ence on the T cell subsets, serum CA125 and IL-6 levels. Methods： Sixty-seven patients with cervical cancer treated in our hospital from April 2015 to March 2017 were randomly divided into the observation group and the control group. The patients in control group were treated with chemotherapy, while the observation group was treated by matrine injection based on the control group. Then the levels of T cell subsets, changes of serum CA125 and IL-6 levels before and after treatment, improvement of tumor lesion area, clinical efficacy and incidence of adverse reactions were observed and compared between two groups. Results： After treatment, the incidence of adverse reac- tions such as liver and kidney injury and gastrointestinal tract reaction, serum CA125 and IL-6 levels in the observation group were sig- nificantly lower than those of the control group, and the total effective rate （81.58%） was significantly higher than that in the control group （P〈0.05）, the levels of CD3＋, CD4＋ and CD4/CD8＋ in the observation group were significantly higher than those in the control group （50.00%）, while the level ofCD8＋ in the observation group was significantly lower than that in the control group （P〈0.05）. Conclu- sion： Matrine injection showed significant sensitization effect on the cervical cancer, which can effectively reduce the levels of serum CA125 and IL-6, and improve the immune function ofT cells.