血必净注射液联合替加环素治疗脓毒症休克患者的临床疗效观察

Observation on the Curative Effect of Xuebijing Injection Combined with Tigecycline on the Patients with Septic Shock

目的:研究血必净注射液联合替加环素治疗脓毒症休克患者的临床疗效。方法:选取2015年9月至2016年8月我院收治的86例脓毒症休克患者,根据患者入院顺序分为观察组和对照组,42例每组。对照组使用血必净注射液完成治疗,观察组在此基础上加以替加环素。比较两组患者治疗前后APACHEII评分、尿量、血清LAC、血尿素氮(BUN)、肌酐(SCr)、炎性因子及心肌酶水平的变化。结果:治疗后,两组患者APACHEII评分均较治疗前显著降低(P<0.05),尿量均较治疗前显著增加(P<0.05),和对照组相比,观察组的APACHEII评分较低(P<0.05),尿量较多(P<0.05);两组患者血清LAC、BUN、SCr、IL-6、CRP、TNF-α、CK-MB、c Tn I、LDH水平较治疗前显著降低(P<0.05),且观察组的以上指标水平较对照组显著降低(P<0.05)。结论:血必净注射液联合替加环素治疗脓毒症休克患者能有效改善患者病情严重程度,提高患者心肾功能并抑制炎症反应,临床疗效较单用血必净注射液更好。

Objective： To study the clinical efficacy of Xuebijing injection combined with tigecycline in the treatment of septic shock patients. Methods： From September 2015 to August 2016, 86 cases of patients with septic shock were enrolled in our hospital. Ac- cording to the order of admission, the patients were divided into the observation group and the control group. The control group was treated with Xuebijing injection, and the observation group was treated with tigecycline on the basis of control group. The changes of APACHEII score, urine volume, serum LAC, blood urea nitrogen （BUN）, creatinine （SCr）, inflammatory factors and myocardial enzyme levels were compared between the two groups before and after treatment. Results： After treatment, the APACHEII scores of both groups were significantly lower than those before treatment （P〈0.05）, and the urine output were significantly higher than those before treatment （P〈0.05）. Compared with the control group, the APACHEII score of observation group was lower （P〈0.05）, the urine output was higher （P〈0.05）. The levels of serum LAC, BUN, SCr, IL-6, CRP, TNF-α, CK-MB, cTnl and LDH of both groups were significantly lower than those before treatment （P〈0.05）, and the levels of above indicators in the observation group were significantly lower than those of the control group （P〈0.05）. Conclusion： Xuebijing injection combined with tigecycline can effectively improve the heart and kidney function and inhibit the inflammatory response in the treatment of patients with sepsis shock, the clinical efficacy is better compared with the use of Xuebijing injection alone.