1-乙氧基-4-羟基-2,2,6,6-四甲基哌啶醇的合成

Synthesis of 1-ethoxy-2,2,6,6-tetramethylpiperidine-4-ol

以4-羟基-2,2,6,6-四甲基哌啶氮氧自由基(ZJ-701)和丁酮为原料,质量分数30%的H_2O_2为氧化剂,CuCl为还原剂,通过自由基反应合成了1-乙氧基-4-羟基-2,2,6,6-四甲基哌啶醇,并通过红外光谱、核磁共振氢谱、核磁共振碳谱和质谱表征了其结构。结果表明,其较佳工艺条件为n(ZJ-701)∶n(丁酮)∶n(H_2O_2)∶n(CuCl)=1∶12∶5∶0.05,反应时间18h,反应温度30℃。在此条件下,产品的产率为56.5%,质量分数为98.91%。

1-Ethoxy-2,2,6,6-tetramethylpiperidine-4-ol was synthesized through O-alkylation reaction by using 4-hydroxy-2,2,6,6-tetramethyl-piperidinooxy（（ZJ-701）and 2-butanone as raw materials,30%H2 O2 as oxidant,CuCl as reducing agent,and its structure was charateristized by IR,1 H NMR、13 C NMR and MS.The results revealed that its optimal conditions were as follows：n（ZJ-701）∶n（butanone）∶n（H2 O2）∶n（CuCl）=1∶12∶5∶0.05,the reaction time being 18 h,and the reaction temperature being 30℃.Under the above conditions,the yield of the products was 56.5%and the purity was 98.91%.