O型血孕妇IgG抗体效价与HDN相关性分析

Analysis of the relationship between IgG antibody titer and HDN in o-type blood pregnant women

目的探讨新生儿溶血病(HDN)与O型血孕妇产前血清中IgG抗体效价之间的关系。方法对515例O型血而丈夫非O型血孕妇做IgG抗A(B)效价测定,其中246例有HDN危险的孕妇所生新生儿做HDN血型血清学检查。结果首次妊娠孕妇IgG抗A(B)抗体阳性率明显低于两次妊娠孕妇;在夫妻血型抗体效价≥64中,O-A血型为42.8%,O-B血型为40.8%,O-AB血型为44.4%;当IgG抗A(B)抗体效价≥64时,抗体效价越高HDN的发病率越高。结论 IgG抗A(B)效价与妊娠次数呈正相关;O型血孕妇检测到的血清中IgG抗A(B)效价高低与ABO-HDN的发生率呈正相关。因此,在孕妇分娩之前进行血清IgG抗体效价检测是很有必要的。

Objective To investigate the relationship between neonatal hemolytic disease（HDN）and IgG antibody titer in prenatal serum of O-type pregnant women.Methods Serum anti-A（B）titer was determined in 515 pregnant women with Otype blood whose husbands were with non-O-type blood,and the HDN blood group serology was performed on the newborn infants with HDN risk.Results The positive rate of IgG anti-A（B）antibodies in the first pregnant women was significantly lower than that of the second pregnant women.In the blood type of antibody titers≥64,the blood type of O-A was 42.8%,the blood type of O-B was 40.8%,and the blood type of O-AB was 44.4%.When the IgG anti-A（B）antibody titer is≥64,if the antibody titer is higher,the incidence of HDN is higher.Conclusion The titer of IgG anti-A（B）was positively correlated with the number of gestational pregnancies.The level of serum IgG anti-A（B）titer detected by O-type pregnant women was positively correlated with the incidence of ABO-HDN.Therefore,in pregnant women before delivery of serum IgG antibody titer is necessary.