间歇式静电纺丝制备纳米纤维药物控释系统

Nanofiber Prepared by Intermittent Electrospun as Controlled Drug Delivery

利用间歇式静电纺丝技术,分别以聚乳酸(PLLA)、聚己内酯(PCL)、聚乙烯吡咯烷酮(PVP)、聚丙烯腈(PAN)、聚乙二醇(PEG)等高分子材料单独或以不同配比制备纳米纤维.针对纺丝过程中容易出现的黏连现象,通过间歇式静电纺丝技术的控制,有效避免了黏连.对所得纳米纤维产品的形貌、结构、性质进行表征,初步考察所制备的纳米纤维在不同溶液中的降解行为,以选择合适的体系作为可控降解的载体担载不同的药物,构建载药复合纳米纤维.

Biodegradable polymers, such as polylactic acid （PLLA）, poly-ε-caprolactone （ PCL）, polyvinylpyrrolidone （PVP）, polyacrylonitrile （PAN）, polyethylene glycol （PEG）, etc. with different ratios were intermittent electrospun to obtain nanofibers. The morphologies, structures, and properties of those nanofibers were characterized by SEM, XRD, FT-IR, etc. The degradation behavior of nanofibers was investigated in different solution. By analyzing the use of different degradation behaviors, the carrier for different types of DDS was preliminarily discussed for choosing suitable controllable-degradation carrier for different drugs to construct drug composite nanofibers.