慢性HBV病毒感染与骨质疏松症之间的关系研究

Study on the relationship between chronic HBV infection and osteoporosis

目的研究乙型肝炎病毒(hepatitis B virus,HBV)感染与骨质疏松症之间的相关性。方法对2008年1月至2016年1月我院收治的10000例患者的临床资料作回顾性分析,其中2145例HBV感染者和2145例非HBV感染者分别归为研究组和对照组。分析研究HBV感染与骨质疏松症之间的相关性。结果研究组和对照组的年龄、性别、合并症以及药物使用分布等一般资料之间的差异没有统计学意义(P>0.05)。感染HBV病毒和未感染HBV病毒的患者骨质疏松症的发病率分别为0.28%和0.26%,调整年龄、性别、合并症、药物治疗等因素后骨质疏松症的风险比(95%CI)为1.15(1.02~1.27)。HBV感染引起的骨质疏松风险随年龄而下降,对于年龄≤49岁的患者,HBV感染患者的骨质疏松症风险显著高于无HBV感染者,风险比为1.43(1.17~1.72)。HBV感染引起的骨质疏松症风险随着合并症的发生而降低,有合并症的风险比为1.02(0.90~1.17),无合并症的风险比为1.26(1.08~1.49)。结论 HBV增加骨质疏松的风险,但HBV感染的影响较小,HBV对骨质疏松性骨折无影响。

Objective To study the correlation between hepatitis B virus（ HBV） infection and osteoporosis（ OP）. Methods The clinical data of 10000 patients admitted to our hospital from January 2008 to January 2016 were analyzed retrospectively. Among them,2145 HBV infection patients and 2145 non-HBV patients were classified as study group and control group,respectively. The correlation between HBV infection and osteoporosis were analyzed. Results There were no statistically significant differences in age,sex,comorbidities,and drug use profiles between the study group and the control group（ P〈0. 05）. The incidence of osteoporosis in patients infected with HBV and non-infected patients was 0. 28 and 0. 26 per 100 person-years,respectively. After adjustment of age,sex,comorbidities,drug therapy and other factors,the risk of osteoporosis（ 95%CI） was 1. 15（ 1. 02—1. 27）in HBV infection patients. The risk of osteoporosis in HBV infection decreased with age,for patients younger than 49 years of age,the risk of osteoporosis in patients with HBV infection was significantly higher than those with no HBV infection,with a risk ratio of1. 43（ 1. 17—1. 72）. The risk of osteoporosis caused by HBV infection decreased with the occurrence of comorbidities,with a risk ratio of 1. 02（ 0. 90—1. 17） in those with comorbidities,and of 1. 26（ 1. 08—1. 49） in those with no comorbidities. Conclusion HBV increased the risk of osteoporosis,but the impact was little and HBV has no effect on osteoporotic fractures.