ADA和CRP在结核性脑膜炎和化脓性脑膜炎诊断中的价值分析

Value Analysis of ADA and CRP in Diagnosis of Tuberculous Meningitis and Suppurative Meningitis

目的通过检测脑膜炎患者血液和脑脊液(CSF)中的腺苷脱氨酶(ADA)的含量,同时对患者血液中的C-反应蛋白(CRP)含量检测,用来对结核性脑膜炎与化脓性脑膜炎进行鉴别。方法选取2015年3月至2016年3月的120例儿科脑膜炎患者,依据不同性质脑膜炎分为结核性脑膜炎患者40例和化脓性脑膜炎患者40例,病毒性以及其他脑膜炎作参照组40例,采取其患者血液及脑脊液作ADA与CRP进行生化检测,将三组ADA和CRP的结果进行分析对比。结果三组脑膜炎患者脑脊液ADA、血清ADA、血清CRP的对比情况中,结核性组与化脓性组的对比差异具有统计学意义(P<0.05),参照组与结核性组比较差异具有统计学意义(P<0.05),参照组与化脓性组相比较差异不具有统计学意义(P>0.05)。结论 ADA和CRP检测对于早期的结核性脑膜炎和化脓性脑膜炎的鉴别诊断价值比较大,值得临床推广。

Objective Through testing in patients with meningitis of adenosine deoxidizing enzyme levels in the blood and brain fluid, at the same time for the patient of c-reactive protein in the blood containing, used to identify tuberculous meningitis and purulent meningitis. Selection Methods March 2015-March 2016 of the 120 cases, according to the different nature of meningitis is divided into pediatric patients with 40 patients with tuberculous meningitis and purulent meningitis 40 cases, viral and other meningitis as a control group 40 cases, take the patient＇s blood and brain fluid biochemical tests for ADA and CRP, the comparative analysis results of three groups of ADA and CRP. Results The three groups of patients with meningitis in ADA, serum, CFS contrast cases, tuberculous and pyogenic group contrast differences statistically significant（P〈0.05）, control group compared with tuberculous group differences statistically significant（P〈0.05）, control group no statistically significant difference compared with pyogenic group（P〈0.05）. Conclusion ADA and CRP detection are valuable for the differential diagnosis of tuberculous meningitis and suppurative meningitis in the early stage.