冠心病心绞痛证候要素与病程的Logistic回归分析

Syndrome Factors and Course Logistic Regression Analysis of Angina Pectoris In Coronary Heart Disease

目的:探讨冠心病心绞痛证候要素与病程的关系,明确冠心病心绞痛发病的证候要素,总结冠心病心绞痛的病机演变规律。方法:运用临床流行病学调查方法,收集492例经过冠脉造影检查的患者,其中冠心病心绞痛患者353例,非冠心病心绞痛患者139例,并运用SPSS13.0统计软件对数据进行二值Logistic回归分析。结果:11个证候要素中血瘀、血虚、气滞、气虚、内毒、寒凝、痰浊、阳虚是冠心病心绞痛发病的危险因素,随着病程的延长,病机演变规律为气血不足→气滞血瘀、内毒产生→脉络损伤、痰浊内生→阳气损伤、寒凝脉络→肾虚水停。结论:冠心病心绞痛的病机随着病程的延长,证候演变具有一定的规律。

Objective： Through explore the correlation between syndrome factors and course of disease with angina pectoris,to clarify the syndrome factors of angina pectoris and summarize the pathogenesis of angina pectoris. Methods Use of clinical epidemiological survey method,a total of 492 patients undergoing coronary angiography were enrolled,including353 cases of angina pectoris and 139 cases of non angina pectoris. SPSS13. 0 was used to analyze the data by binary logistic regression analysis. Results The blood stasis,blood deficiency,qi stagnation,qi deficiency,internal poisoning,cold coagulation,phlegm turbidity and yang deficiency were the risk factors of angina pectoris in 11 syndromes. With the prolongation of disease duration,the evolution of pathogenesis was： Blood deficiency→qi stagnation,stagnation heat→vein injury,phlegm endogenous→Yang injury,cold coagulation→Kidney weakness and water stop. Conclusion The pathogenesis of angina pectoris has a certain regularity with the course of disease.