肠道微生态调节在外科营养治疗中的作用

Role of intestinal micro-ecological regulation in surgical nutrition therapy

人体肠道内动态定植着机体最庞大、有着重要生理功能的微生态系统,其对宿主的健康起着重要作用,是激活和维持肠道生理功能的关键因素。外科相当一部分病人由于肠道功能和生理结构发生根本性改变,必然带来肠道微生态的影响,而在临床营养治疗过程中,长期禁食、应用制酸剂及疾病本身的应激更会导致微生态系统的破坏,伴随的肠源性感染、抗生素耐药等增加了治疗风险并延长了住院时间。因此,在肠道微生态重要性日益凸显的背景下,在外科营养治疗中如何兼顾纠正肠道菌群紊乱、保护肠屏障、加速康复是一个值得关注的问题。

Microecosystem with important physiological functions are dynamically colonized in the human gut, which plays an important role in the health of the host and is a key factor in activating and maintaining intestinal physiological functions.In surgery, a considerable number of patients are bound to be affected by intestinal microbiota due to the fundamental changes in intestinal function and physiological structure. But in the course of clinical nutrition treatment, long-term fasting, application of antacids and the stress of the disease itself can lead to the destruction of micro-ecosystems. Concomitant intestinal infections, antibiotic resistance and so on increase the risk of treatment and prolong the length of stay. Therefore, in the context of the growing importance of gut microecology, how to correct the disturbance of intestinal flora, protect the gut barrier and accelerate the recovery in thesurgical nutrition treatment is a concern.